Hydrochloric Acid → HCID 69066440, compound

HRID 1986550Notes

Reaction equation

HRID 1986550 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:26]=[C:27]([F:29])[CH:28]=1)[CH2:5][N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[S:10][CH2:9][CH:8]([NH:17]C(=O)OC(C)(C)C)[C:7]1=[O:25].[ClH:30]>O1CCOCC1>[ClH:30].[NH2:17][CH:8]1[C:7](=[O:25])[N:6]([CH2:5][C:4]2[CH:3]=[C:2]([F:1])[CH:28]=[C:27]([F:29])[CH:26]=2)[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[S:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57722259HCID 57722259, compound

Product 1

HCID 69066440HCID 69066440, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

520 mg of 53 (1.24 mmol) are taken up in a 25 ml round-bottomed flask and 10 ml of a solution of hydrogen chloride in dioxane (4M) are added. The mixture is stirred for 3 hours at room temperature under argon. After evaporating off the solvent, 470 mg of amine 54 are obtained in hydrochloride form, which product is used directly in the following step.

Workup

  1. customAfter evaporating off the solvent, 470 mg of amine 54
  2. customare obtained in hydrochloride form, which product

Sources & evidence

ORD record
ord-58fed9c6166f47a0be4635d0417c3214
Source dataset
uspto-grants-2009_06
Patent number
US07550453B2

Reaction notes

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