Hydrochloric Acid → HCID 69061530, compound

HRID 1986552Notes

Reaction equation

HRID 1986552 reaction equation
[CH2:1]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[S:8][CH2:7][CH:6]([NH:15]C(=O)OC(C)(C)C)[C:5]1=[O:23])[CH:2]=[CH2:3].[ClH:24]>O1CCOCC1>[ClH:24].[NH2:15][CH:6]1[C:5](=[O:23])[N:4]([CH2:1][CH:2]=[CH2:3])[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[S:8][CH2:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57722305HCID 57722305, compound

Product 1

HCID 69061530HCID 69061530, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

610 mg of 56 (1.82 mmol) are taken up in a 25 ml round-bottomed flask and 15 ml of a solution of hydrogen chloride in dioxane (4M) are added. The mixture is stirred for 3 hours at room temperature under argon. After evaporating off the solvent, a gummy residue is obtained, which is triturated from isopropyl ether to give, after filtration, 441 mg of amine 57 in hydrochloride form (cream-colored solid).

Workup

  1. customAfter evaporating off the solvent
  2. customa gummy residue is obtained
  3. customwhich is triturated from isopropyl ether
  4. customto give
  5. filtrationafter filtration, 441 mg of amine 57 in hydrochloride form (cream-colored solid)

Sources & evidence

ORD record
ord-afddc91896a14720a1809ab0800ef02a
Source dataset
uspto-grants-2009_06
Patent number
US07550453B2

Reaction notes

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