反应详情

16 g of 8-methoxy-3-methyl-1-propyl-imidazo[1,5-a]pyrido[3,2-e]pyrazine-4-one and 120 ml POCl3 are mixed and heated up to reflux for 8 hours. After cooling to room temperature the reaction mixture is treated with 1200 ml crushed ice/water and stirred for 1 hour. The product is extracted with 2×300 ml dichloromethane. The collected organic layer is washed with 2×300 ml water and dried with Na2SO4. The solvent is removed under reduced pressure.

1. temperatureheated up
2. temperatureto reflux for 8 hours
3. additionis treated with 1200 ml
4. extractionThe product is extracted with 2×300 ml dichloromethane
5. washThe collected organic layer is washed with 2×300 ml water
6. dry with materialdried with Na2SO4
7. customThe solvent is removed under reduced pressure