Triethylamine → HCID 68868496, compound

HRID 1986597Notes

Reaction equation

HRID 1986597 reaction equation
Cl[C:2]1[C:7]2[N:8]=[CH:9][C:10]3[N:11]([CH2:12][N:13]([O:15][CH3:16])[CH:14]=3)[C:6]=2[N:5]([CH2:17][CH2:18][CH3:19])[CH2:4][C:3]=1[CH3:20].C(N(CC)CC)C.[H][H]>C(O)C.[Pd]>[CH3:16][O:15][N:13]1[CH:14]=[C:10]2[CH:9]=[N:8][C:7]3[CH:2]=[C:3]([CH3:20])[CH2:4][N:5]([CH2:17][CH2:18][CH3:19])[C:6]=3[N:11]2[CH2:12]1

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 68867784HCID 68867784, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 68868496HCID 68868496, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Conditions

Temperature
30 °C

Procedure

2 g of intermediate A1 are suspended in 50 ml ethanol. 1 ml triethylamine and 1 g palladium catalyst are added. An autoclave is used as reaction vessel. Hydrogen is pressed in up to 20 bar pressure. Now, the mixture is stirred at 30° C. for 4 hours. After filtration the solvent is removed. The crude product is dissolved in 100 ml dichloromethane. This solution is washed with 50 ml water. The solvent is removed to isolate pure product.

Workup

  1. customAn autoclave is used as reaction vessel
  2. filtrationAfter filtration the solvent
  3. customis removed
  4. dissolutionThe crude product is dissolved in 100 ml dichloromethane
  5. washThis solution is washed with 50 ml water
  6. customThe solvent is removed
  7. customto isolate pure product

Sources & evidence

ORD record
ord-324f766928b4429fad06fde222953d44
Source dataset
uspto-grants-2009_06
Patent number
US07550465B2

Reaction notes

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