反应详情

To a suspension prepared of 20.0 g KOH (solid), 25.8 g 4-methyl-2-propyl imidazole and 130 ml dimethyl formamide were added 38.0 g 2-chloro-6-methoxy-3-nitro pyridine in small amounts at a reaction temperature of 5° C. The reaction mixture was stirred for 75 minutes at room temperature. Then the reaction mixture was poured in 600 ml water. The mixture was further stirred for 1 hr. The desired product precipitated during this time. The resulting solid was collected by filtration, washed with 100 ml water for 3 times and dried in a dry box with vacuum (40° C.).

1. stirringThe mixture was further stirred for 1 hr
2. customThe desired product precipitated during this time
3. filtrationThe resulting solid was collected by filtration
4. washwashed with 100 ml water for 3 times
5. customdried in a dry box with vacuum (40° C.)