HRID1986661

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2736982

4-methyl-1,2,3-thiadiazole-5-carbonyl chloride

C4H3ClN2OS

HCID4738390

5-Methoxynicotinic acid

C7H7NO3

结构：COc1c(NC(=O)c2cc3cccc(-c4ncccc4C(N)=O)c3s2)cc(C(C)(C)C)cc1NS(C)(=O)=O

HCID86590363

未命名化合物

PRODUCTS

生成物

结构：COc1c(NC(=O)c2cc3cccc(NC(=O)c4snnc4C)c3s2)cc(C(C)(C)C)cc1NS(C)(=O)=O

HCID57722421

未命名化合物

收率 50%

PROCEDURE

实验过程

Was prepared as described for -[2-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-benzo[b]thiophen-7-yl]-nicotinamide starting with 5-methoxy-nicotinic acid to provide 20 mg (50%) of the title compound 4-Methyl-[1,2,3]thiadiazole-5-carbonyl chloride.

WORKUP

后处理

customWas prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cfa5c9644a9d45e5b6ed9100b4336125
来源数据集: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07550461B2
来源说明: uspto-grants-2009_06

反应 SMILES

[C:1]([C:5]1[CH:6]=[C:7]([NH:34][S:35]([CH3:38])(=[O:37])=[O:36])[C:8]([O:32][CH3:33])=[C:9]([NH:11][C:12]([C:14]2[S:18][C:17]3[C:19](C4N=CC=CC=4C(N)=O)=[CH:20][CH:21]=[CH:22][C:16]=3[CH:15]=2)=[O:13])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].COC1C=[N:43]C=C(C=1)C(O)=O.[CH3:50][C:51]1[N:52]=[N:53][S:54][C:55]=1[C:56](Cl)=[O:57]>>[C:1]([C:5]1[CH:6]=[C:7]([NH:34][S:35]([CH3:38])(=[O:36])=[O:37])[C:8]([O:32][CH3:33])=[C:9]([NH:11][C:12]([C:14]2[S:18][C:17]3[C:19]([NH:43][C:56]([C:55]4[S:54][N:53]=[N:52][C:51]=4[CH3:50])=[O:57])=[CH:20][CH:21]=[CH:22][C:16]=3[CH:15]=2)=[O:13])[CH:10]=1)([CH3:3])([CH3:4])[CH3:2]