Methanesulfonyl chloride → HCID 86598049, compound

HRID 1986926Notes

Reaction equation

HRID 1986926 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][C:7](=[O:17])[C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH3:16])=[CH:10][CH:9]=1.C(N(C(C)C)CC)(C)C.[CH3:27][S:28](Cl)(=[O:30])=[O:29]>C(Cl)Cl>[CH3:27][S:28]([OH:30])(=[O:1])=[O:29].[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][C:7](=[O:17])[C:8]1[CH:9]=[CH:10][C:11]([O:14][CH2:15][CH3:16])=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 31297Methanesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 231368204-Ethoxy-N-(4-hydroxybutyl)benzamide

Product 1

HCID 86598049HCID 86598049, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
6 °C

Procedure

A 22-L, 3-necked, round-bottom flask equipped with a mechanical stirrer, nitrogen bubbler, and a thermocouple probe, was charged with 2.00 kg (8.43 mole) of N-(4-hydroxybutyl)-4-ethoxybenzamide (V-5), 2.94 L (2.18 kg, 16.85 mole, 2.00 eq) of diisopropylethylamine, and 11 L of DCM. The white slurry was cooled to 6° C., and 718 mL (1.062 kg, 9.27 mole, 1.10 eq) of methanesulfonyl chloride was added over a period of 1.5 h while maintaining a pot temperature of 5-12° C. with cooling. After stirring for 10 min at 5-10° C. the pale-brown solution was quenched into an extractor that contained 14 L of 1 N HCl. The phases were separated. The organic extract was washed with 14 L of 1 N HCl, washed with 9 L of saturated aq. NaHCO3, dried (MgSO4), filtered and concentrated (30° C., 50 mbar), to give, after air drying, 2.65 kg (99.7%) of N-(4-hydroxybutyl)-4-ethoxybenzamide methanesulfonate (V-6) as a pale-beige solid.

Workup

  1. temperaturewhile maintaining a pot temperature of 5-12° C.
  2. temperaturewith cooling
  3. customwas quenched into an extractor that
  4. customThe phases were separated
  5. extractionThe organic extract
  6. washwas washed with 14 L of 1 N HCl
  7. washwashed with 9 L of saturated aq. NaHCO3
  8. dry with materialdried (MgSO4)
  9. filtrationfiltered
  10. concentrationconcentrated (30° C., 50 mbar)
  11. customto give
  12. customafter air drying

Sources & evidence

ORD record
ord-9c02989ad32e4c75a871e355fb45b257
Source dataset
uspto-grants-2009_06
Patent number
US07550469B2

Reaction notes

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