Hydrogen Bromide → HCID 23112415, compound

HRID 1986950Notes

Reaction equation

HRID 1986950 reaction equation
COC([N:5]1[CH2:10][CH2:9][CH:8]([C:11]2[C:12]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:13]=3[S:14][CH:15]=2)[CH2:7][CH2:6]1)=O.[BrH:24]>>[BrH:24].[F:23][C:20]([F:21])([F:22])[C:17]1[CH:18]=[CH:19][C:12]2[C:11]([CH:8]3[CH2:7][CH2:6][NH:5][CH2:10][CH2:9]3)=[CH:15][S:14][C:13]=2[CH:16]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 58817563HCID 58817563, compound

Product 1

HCID 23112415HCID 23112415, compoundYield 94%

Procedure

A mixture of 4-(6-trifluoromethyl-benzo[b]thiophen-3-yl)-piperidine-1-carboxylic acid methyl ester (3.1 g, 9.0 mmol) in HBr (45 mL, 30% in acetic acid) was stirred at room temperature for 20 hours wher the volatiles were removed in vacuo. The residue was washed with EtOAc and the product was collected by filtration yielding 3.09 g (94%) of the desired product as a white solid.

Workup

  1. customwere removed in vacuo
  2. washThe residue was washed with EtOAc
  3. filtrationthe product was collected by filtration

Sources & evidence

ORD record
ord-8dcc0f6530c14d43a1fa2d20fd227357
Source dataset
uspto-grants-2009_06
Patent number
US07550469B2

Reaction notes

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