Hydrochloric Acid → HCID 68456839, compound

HRID 1986955Notes

Reaction equation

HRID 1986955 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[C:15]3[S:26][CH:25]=[CH:24][C:16]=3[N:17]([CH2:19][C:20]([F:23])([F:22])[F:21])[N:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:27]>>[ClH:27].[NH:8]1[CH2:9][CH2:10][CH:11]([C:14]2[C:15]3[S:26][CH:25]=[CH:24][C:16]=3[N:17]([CH2:19][C:20]([F:23])([F:22])[F:21])[N:18]=2)[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 58817532HCID 58817532, compound

Product 1

HCID 68456839HCID 68456839, compoundYield 74%

Procedure

4-[1-(2,2,2-Trifluoro-ethyl)-1H-thieno[3,2-c]pyrazol-3-yl]-piperidine-1-carboxylic acid tert-butyl ester (1.9 g, 4.87 mmol) was stirred at room temperature in a solution of HCl (6 mL, 4N HCl in dioxane) for 4 hours. The volatiles were removed in vacuo and the residue was triturated with ether (twice) to yield off white solids 2.1 g (74%) as the desired hydrochloride salt.

Workup

  1. customThe volatiles were removed in vacuo
  2. customthe residue was triturated with ether (twice)

Sources & evidence

ORD record
ord-9d3f0c71e3684e78a7c6ea8c10a3587f
Source dataset
uspto-grants-2009_06
Patent number
US07550469B2

Reaction notes

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