Hydrochloric Acid → HCID 23112509, compound

HRID 1986957Notes

Reaction equation

HRID 1986957 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:18]3[S:19][CH:20]=[CH:21][C:17]=3[O:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>>[N:11]1([C:14]2[C:18]3[S:19][CH:20]=[CH:21][C:17]=3[O:16][N:15]=2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 68460799HCID 68460799, compound

Product 1

HCID 23112509HCID 23112509, compoundYield 97.3%

Procedure

4-Thieno[2,3-d]isoxazol-3-yl-piperazine-1-carboxylic acid tert-butyl ester (5.0 g, 16.2 mmol) was stirred at room temperature in a solution of HCl (25 mL, 4N HCl in dioxane) for 4 hours. The volatiles were removed in vacuo and the residue was triturated with ether (twice) to yield off white solids 3.3 g (84%) as the desired hydrochloride salt.

Workup

  1. customThe volatiles were removed in vacuo
  2. customthe residue was triturated with ether (twice)

Sources & evidence

ORD record
ord-2898ebde99794d01a30aafc9f819ea4f
Source dataset
uspto-grants-2009_06
Patent number
US07550469B2

Reaction notes

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