Hydrochloric Acid → HCID 68827965, compound

Participants

Reaction Steps

Prepared from N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-[6-cyano-3-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-2-fluoro-phenyl]-acetamide, as described in the previous step, using essentially the protocol given in Example 1m. 1H NMR (300 Hz, CD3OD) δ 8.69 (d, J=4.6 Hz, 1H), 8.10-8.00 (m, 1H), 7.83 (d, J=9.2 Hz, 1H), 7.77 (d, J=7.9 Hz, 1H), 7.67-7.57 (m, 1H), 7.33-7.24 (m, 1H), 6.91-6.78 (m, 2H), 4.27 (s, 2H), 4.13 (t, J=13.8 Hz, 2H), 3.74 (d, J=1.98 Hz, 2H), 2.51 (s, 3H); LC/MS (m/z) [M+1]+455.1 (calculated for C23H21F3N6O, 454.17). Elem. Anal. Calc. for free base •2.0 HCl •0.75H2O: C, 51.07; H, 4.57; N, 15.54. Found: C, 50.85; H, 4.31; N, 15.40.

Provenance & Evidence