Hydrochloric Acid → HCID 68827965, compound

HRID 1987065Notes

Reaction equation

HRID 1987065 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][NH:10][C:11](=[O:33])[CH2:12][C:13]2[C:18]([C:19]#[N:20])=[CH:17][CH:16]=[C:15]([NH:21][CH2:22][C:23]([F:31])([F:30])[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=3)[C:14]=2[F:32])=[CH:4][CH:3]=1.[ClH:34]>>[ClH:34].[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][NH:10][C:11](=[O:33])[CH2:12][C:13]2[C:18]([C:19]#[N:20])=[CH:17][CH:16]=[C:15]([NH:21][CH2:22][C:23]([F:30])([F:31])[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=3)[C:14]=2[F:32])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 11236372HCID 11236372, compound

Product 1

HCID 68827965HCID 68827965, compound

Procedure

Prepared from N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-[6-cyano-3-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-2-fluoro-phenyl]-acetamide, as described in the previous step, using essentially the protocol given in Example 1m. 1H NMR (300 Hz, CD3OD) δ 8.69 (d, J=4.6 Hz, 1H), 8.10-8.00 (m, 1H), 7.83 (d, J=9.2 Hz, 1H), 7.77 (d, J=7.9 Hz, 1H), 7.67-7.57 (m, 1H), 7.33-7.24 (m, 1H), 6.91-6.78 (m, 2H), 4.27 (s, 2H), 4.13 (t, J=13.8 Hz, 2H), 3.74 (d, J=1.98 Hz, 2H), 2.51 (s, 3H); LC/MS (m/z) [M+1]+455.1 (calculated for C23H21F3N6O, 454.17). Elem. Anal. Calc. for free base •2.0 HCl •0.75H2O: C, 51.07; H, 4.57; N, 15.54. Found: C, 50.85; H, 4.31; N, 15.40.

Sources & evidence

ORD record
ord-38ae794e9ec84bb4bc081d5d1751263e
Source dataset
uspto-grants-2009_06
Patent number
US07550474B2

Reaction notes

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