Sodium Hydroxide → HCID 86605105, compound

HRID 1987184Notes

Reaction equation

[Cl:1][C:2]1[N:3]=[CH:4][N:5]([C:16]2[CH:21]=[CH:20][C:19]([S:22]([NH:25][P:26](=[O:29])([OH:28])[OH:27])(=[O:24])=[O:23])=[CH:18][CH:17]=2)[C:6]=1[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[C:9]([F:15])[CH:8]=1.[OH-].[Na+:31]>>[Cl:1][C:2]1[N:3]=[CH:4][N:5]([C:16]2[CH:17]=[CH:18][C:19]([S:22]([NH:25][P:26](=[O:27])([O-:28])[O-:29])(=[O:23])=[O:24])=[CH:20][CH:21]=2)[C:6]=1[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[C:9]([F:15])[CH:8]=1.[Na+:31].[Na+:31].[Na+:31]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 9890518HCID 9890518, compound

Product 1

HCID 86605105HCID 86605105, compound

Procedure

Following a similar procedure to that described in example 2, but using N-[4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]phenylsulfonyl]-phosphoramidic acid (obtained in example 6) instead of diethyl N-[4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]phenylsulfonyl]phosphoramidate and 3 equivalents of NaOH instead of 1, and recrystallizing then the crude product obtained from PriOH, the title compound of the example was obtained as a white solid.

Workup

customrecrystallizing

Sources & evidence

ORD record: ord-4b5d969c580a4d81a12f4dc87153867a
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07550497B2

Reaction notes

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