Sodium Hydroxide → HCID 131727498, compound

HRID 1987186Notes

Reaction equation

HRID 1987186 reaction equation
[Cl:1][C:2]1[N:3]=[CH:4][N:5]([C:16]2[CH:21]=[CH:20][C:19]([S:22]([NH2:25])(=[O:24])=[O:23])=[CH:18][CH:17]=2)[C:6]=1[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH3:15])=[CH:9][CH:8]=1.[OH-].[Na+:27]>CCO>[Na+:27].[Cl:1][C:2]1[N:3]=[CH:4][N:5]([C:16]2[CH:21]=[CH:20][C:19]([S:22]([NH-:25])(=[O:24])=[O:23])=[CH:18][CH:17]=2)[C:6]=1[C:7]1[CH:8]=[CH:9][C:10]([O:13][CH2:14][CH3:15])=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 9907758HCID 9907758, compound

Product 1

HCID 131727498HCID 131727498, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of 4-[4-chloro-5-(4-ethoxyphenyl)imidazol-1-yl]benzenesulfonamide (1 g, 2.89 mmol) (obtained as described in WO 00/23426) in EtOH (55 mL), NaOH powder (115 mg, 2.89 mmol) was added under argon atmosphere, and the resulting mixture was stirred at room temperature for 2 h. The mixture was concentrated to dryness and a crude product was obtained, which was directly used in the following reaction.

Workup

  1. additionwas added under argon atmosphere
  2. concentrationThe mixture was concentrated to dryness

Sources & evidence

ORD record
ord-48ba948c10464b118213ee3d11a1916b
Source dataset
uspto-grants-2009_06
Patent number
US07550497B2

Reaction notes

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