HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(4-(((4,4-Difluorocyclohexyl)methyl)amino)-3-nitrophenyl)ethanesulfonamide → N-(3-amino-4-{[(4,4-difluorocyclohexyl)methyl]amino}phenyl)ethanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(4-(((4,4-Difluorocyclohexyl)methyl)amino)-3-nitrophenyl)ethanesulfonamide | HCID 11516373 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-(3-amino-4-{[(4,4-difluorocyclohexyl)methyl]amino}phenyl)ethanesulfonamide | HCID 11559310 | 103.1% |
Reaction Steps
N-(4-{[(4,4-Difluorocyclohexyl)methyl]amino}-3-nitrophenyl)ethanesulfonamide (23.4 g) and Pd/C 10% in EtOAc (800 mL) were shaken together overnight under H2 atmosphere (50 PSI) in a Parr hydrogenation apparatus. The reaction mixture was diluted with MeOH (400 mL) and filtered over celite bed. The solvent was removed to provide the desired title product (22.2 g) as beige solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07550495B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-87ad012c63f94080a6dfb9d4c3527591 |
| Source note | uspto-grants-2009_06 |