反应详情

N-(4-{[(4,4-Difluorocyclohexyl)methyl]amino}-3-nitrophenyl)ethanesulfonamide (23.4 g) and Pd/C 10% in EtOAc (800 mL) were shaken together overnight under H2 atmosphere (50 PSI) in a Parr hydrogenation apparatus. The reaction mixture was diluted with MeOH (400 mL) and filtered over celite bed. The solvent was removed to provide the desired title product (22.2 g) as beige solid.

1. filtrationfiltered over celite bed
2. customThe solvent was removed