HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium → Butylphthalide impurity
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | Potassium | HCID 5462222 | — |
| Reactant | HCID 23069675 | HCID 23069675 | — |
| Product | Butylphthalide impurity | HCID 11413929 | — |
Reaction Steps
2-(α-hydroxypentyl)benzoate of general formula (I) wherein M is a monovalent metal ion (e.g., sodium or potassium) is solved in a solvent, then a inorganic acid is added to the solution to adjust pH value to 6.0-2.0 at the temperature of −20-20° C., preferably −20-0° C., to acidify the 2-(α-hydroxypentyl)benzoate and 2-(α-hydroxypentyl)benzoic acid is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07550507B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-c65871803dd54b959ce361d401307dad |
| Source note | uspto-grants-2009_06 |