Sodium → Butylphthalide impurity

HRID 1987252Notes

Reaction equation

HRID 1987252 reaction equation
[OH:1][CH:2]([C:7]1[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=1[C:9]([O-:11])=[O:10])[CH2:3][CH2:4][CH2:5][CH3:6].[Na].[K]>>[OH:1][CH:2]([C:7]1[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10])[CH2:3][CH2:4][CH2:5][CH3:6]

Participants

4

Reactant 3

HCID 5360545SodiumHCID 5462222PotassiumHCID 23069675HCID 23069675, compound2×

Product 1

HCID 11413929Butylphthalide impurity

Procedure

2-(α-hydroxypentyl)benzoate of general formula (I) wherein M is a monovalent metal ion (e.g., sodium or potassium) is solved in a solvent, then a inorganic acid is added to the solution to adjust pH value to 6.0-2.0 at the temperature of −20-20° C., preferably −20-0° C., to acidify the 2-(α-hydroxypentyl)benzoate and 2-(α-hydroxypentyl)benzoic acid is obtained.

Workup

  1. additiona inorganic acid is added to the solution
  2. customat the temperature of −20-20° C., preferably −20-0° C.

Sources & evidence

ORD record
ord-c65871803dd54b959ce361d401307dad
Source dataset
uspto-grants-2009_06
Patent number
US07550507B2

Reaction notes

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