Clofibric Acid → HCID 22270411, compound

HRID 1987306Notes

Reaction equation

Cl.[NH2:2][CH:3]([CH:5]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:6][CH:7]([CH3:9])[CH3:8])[CH3:4].[Cl:16][C:17]1[CH:29]=[CH:28][C:20]([O:21][C:22]([CH3:27])([CH3:26])[C:23](O)=[O:24])=[CH:19][CH:18]=1>>[CH3:4][CH:3]([NH:2][C:23](=[O:24])[C:22]([O:21][C:20]1[CH:28]=[CH:29][C:17]([Cl:16])=[CH:18][CH:19]=1)([CH3:27])[CH3:26])[CH:5]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[CH2:6][CH:7]([CH3:9])[CH3:8]

Participants

Reactant 2

HCID 2797Clofibric Acid

HCID 222707032-Amino-5-methyl-3-phenylhexane hydrochloride salt

Product 1

HCID 22270411HCID 22270411, compound

Procedure

2-Amino-5-methyl-3-phenylhexane hydrochloride salt from Reference Example 26 (30 mg) was reacted with the acid chloride prepared from of 2-(4-chlorophenoxy)-2-methyl-propionic acid (37 mg) according to the procedure described in Example 62-63 to afford the title compound after purification by preparative TLC on silica gel eluted with 20% EtOAC-hexane. 1H NMR: (500 MHz, CDCl3): δ 0.83 and 0.85 (2d, 6H), 0.96 (d, 3H), 1.34 (m, 1H), 1.45 (m, 1H), 1.53 (s, 3H), 1.59 (s, 3H), 2.73 (m, 1H), 4.24 (m, 1H), 6.41 (d, 1H), 6.8-7.4 (m, 9H).

Sources & evidence

ORD record: ord-01869e4a1d6f4422ac6c1cf6be896f95
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07550489B2

Reaction notes

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