Acetylglycine → HCID 68819123, compound

HRID 1987487Notes

Reaction equation

HRID 1987487 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=O.[C:13]([NH:16][CH2:17][C:18]([OH:20])=[O:19])(=O)[CH3:14].C([O-])(=O)C.[Na+]>C(OC(=O)C)(=O)C>[CH3:14][C:13]1[O:20][C:18](=[O:19])[C:17](=[CH:5][C:4]2[CH:7]=[CH:8][CH:9]=[CH:10][C:3]=2[C:2]([F:12])([F:11])[F:1])[N:16]=1

Participants

5

Reactant 3

HCID 10972AcetylglycineHCID 123067o-(Trifluoromethyl)benzaldehydeHCID 517045Sodium Acetate

Product 1

HCID 68819123HCID 68819123, compound

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

20 g o-Trifluoromethyl benzaldehyde, 60 g N-acetylglycine and 12 g sodium acetate were stirred in 68.2 g acetic anhydride at 80° C. for 22 hrs. The mixture was poured into 100 ml ice water, the precipitate filtered off and washed with water. Yield 35 g of wet crude product, used without further purification fort the next step.

Workup

  1. filtrationthe precipitate filtered off
  2. washwashed with water

Sources & evidence

ORD record
ord-a9174a47d2f645879adebbe476143936
Source dataset
uspto-grants-2009_06
Patent number
US07550589B2

Reaction notes

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