Benzyl 4-isobutyl-1-piperazinecarboxylate → 1-(2-Methylpropyl)piperazine

HRID 1987554노트

반응식

HRID 1987554 반응식
[CH2:1]([N:5]1[CH2:10][CH2:9][N:8](C(OCC2C=CC=CC=2)=O)[CH2:7][CH2:6]1)[CH:2]([CH3:4])[CH3:3]>C(O)C.[C].[Pd]>[CH2:1]([N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)[CH:2]([CH3:4])[CH3:3]

참가 물질

4

반응물 1

HCID 23069811Benzyl 4-isobutyl-1-piperazinecarboxylate

생성물 1

HCID 20520521-(2-Methylpropyl)piperazine수율 112.9%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

The resulting benzyl 4-isobutylpiperazin-1-carboxylate (1.05 g) was dissolved in 35 mL of ethanol, 10% palladium-carbon (750 mg) was added thereto, and the reaction mixture was stirred at room temperature under hydrogen atmosphere (1 atm) for 12 hours. The palladium-carbon was removed by filtration, and the filtrate was evaporated to give the title compound (610 mg) as a colorless oil.

후처리

  1. customThe palladium-carbon was removed by filtration
  2. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-ba36e911f4cd47d39b1bd4e218a2fe6f
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07550503B2

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