2-Acetamido-5-aminopyridine → HCID 178466025, compound

HRID 1987596Notes

Reaction equation

HRID 1987596 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5]/[C:4](=[C:12]2/[C:13]([CH3:18])=[N:14][NH:15][C:16]/2=[O:17])/[CH:3]=1.[C:19](NC1C=CC(N)=CN=1)(=[O:21])[CH3:20]>C(O)C>[CH2:19]([O:21][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5]/[C:4](=[C:12]2/[C:13]([CH3:18])=[N:14][NH:15][C:16]/2=[O:17])/[CH:3]=1)[CH3:20]

Participants

4

Reactant 2

HCID 27352192-Acetamido-5-aminopyridineHCID 178434119HCID 178434119, compound

Product 1

HCID 178466025HCID 178466025, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
180 °C

Procedure

(Z)-4-(4-chloroquinolin-2(1H)-ylidene)-3-methyl-1H-pyrazol-5(4H)-one (0.033 g, 0.13 mmol) and 2-acetamido-5-aminopyridine (Matrix) (0.058 g, 0.38 mmol) were dissolved in ethanol (1.5 mL). The reaction mixture was heated to 180° C. using a microwave reactor for 6 hrs. The mixture was concentrated and purified by LC-MS to give the title compounds of Example 4 and Example 5.

Workup

  1. customfor 6 hrs
  2. concentrationThe mixture was concentrated
  3. custompurified by LC-MS

Sources & evidence

ORD record
ord-d8d59679e9c241b99da44f5d531574ac
Source dataset
uspto-grants-2009_06
Patent number
US07550598B2

Reaction notes

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