反应详情

To 15.2 g of 1-acetyl-4-(4-imidazol-1-ylphenyl)-piperazine, 100 ml of concentrated hydrochloric acid was added, followed by heating at reflux for 3 hours. After the completion of the reaction, the reaction solution was cooled and then neutralized with an aqueous 1N sodium hydroxide solution, thereby to precipitate a crystal. The resulting crystal was filtrated, washed with a small amount of water and then dried to obtain 12 g of the objective 1-(4-imidazol-1-ylphenyl)-piperazine (melting point: 177-180° C.).

1. temperatureby heating
2. temperatureat reflux for 3 hours
3. customAfter the completion of the reaction
4. temperaturethe reaction solution was cooled
5. customto precipitate a crystal
6. filtrationThe resulting crystal was filtrated
7. washwashed with a small amount of water
8. customdried