反应详情

To 5.1 g of 1-acetyl-4-(4-1H-pyrazol-5-ylphenyl)-piperazine, 60 ml of concentrated hydrochloric acid were added, followed by heating at reflux for 3 hours. After the completion of the reaction, the reaction solution was cooled and then neutralized with an aqueous 1N sodium hydroxide solution, thereby to precipitate a crystal. The resulting crystal was filtered, washed with a small amount of water and then dried to obtain 4.3 g of the objective 1-(4-1H-pyrazol-5-ylphenyl)-piperazine (melting point: 290° C. or higher).

1. temperatureby heating
2. temperatureat reflux for 3 hours
3. customAfter the completion of the reaction
4. temperaturethe reaction solution was cooled
5. customto precipitate a crystal
6. filtrationThe resulting crystal was filtered
7. washwashed with a small amount of water
8. customdried