6-Bromo-2-naphthoyl chloride → 6-Bromo-naphthalene-2-carboxylic acid (2-acetylamino-benzothiazol-4-yl)-amide

HRID 1987815Notes

Reaction equation

HRID 1987815 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12](Cl)=[O:13])[CH:6]=[CH:5]2.[NH2:15][C:16]1[C:21]2[N:22]=[C:23]([NH:25][C:26](=[O:28])[CH3:27])[S:24][C:20]=2[CH:19]=[CH:18][CH:17]=1>>[C:26]([NH:25][C:23]1[S:24][C:20]2[CH:19]=[CH:18][CH:17]=[C:16]([NH:15][C:12]([C:7]3[CH:6]=[CH:5][C:4]4[C:9](=[CH:10][CH:11]=[C:2]([Br:1])[CH:3]=4)[CH:8]=3)=[O:13])[C:21]=2[N:22]=1)(=[O:28])[CH3:27]

Participants

3

Reactant 2

HCID 218796066-Bromo-2-naphthoyl chlorideHCID 22135520N-(4-amino-benzothiazol-2-yl)-acetamide

Product 1

HCID 116836276-Bromo-naphthalene-2-carboxylic acid (2-acetylamino-benzothiazol-4-yl)-amide

Procedure

This material was prepared analogous to the procedure described for Example 1(b). 6-Bromo-naphthalene-2-carbonyl chloride, Example 1(a), (98 mg, 0.36 mmol) reacted with N-(4-amino-benzothiazol-2-yl)-acetamide (50 mg, 0.24 mmol, prepared according to the procedure described in WO03099284) to give the title compound as a solid. Mp 241.6° C. MS (ESI, pos. ion.) m/z: 441 (M+1).

Workup

  1. customThis material was prepared analogous to the procedure
  2. customprepared

Sources & evidence

ORD record
ord-921e04b6985d4303a92e2161b3d9912e
Source dataset
uspto-grants-2009_06
Patent number
US07553848B2

Reaction notes

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