3-Aminoquinoline → 6-Bromo-naphthalene-2-carboxylic acid quinolin-3-ylamide

HRID 1987817Notes

Reaction equation

HRID 1987817 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12](Cl)=[O:13])[CH:6]=[CH:5]2.[NH2:15][C:16]1[CH:17]=[N:18][C:19]2[C:24]([CH:25]=1)=[CH:23][CH:22]=[CH:21][CH:20]=2>>[N:18]1[C:19]2[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:25]=[C:16]([NH:15][C:12]([C:7]2[CH:6]=[CH:5][C:4]3[C:9](=[CH:10][CH:11]=[C:2]([Br:1])[CH:3]=3)[CH:8]=2)=[O:13])[CH:17]=1

Participants

3

Reactant 2

HCID 113753-AminoquinolineHCID 218796066-Bromo-2-naphthoyl chloride

Product 1

HCID 115380936-Bromo-naphthalene-2-carboxylic acid quinolin-3-ylamide

Procedure

This material was prepared analogous to the procedure described for Example 1(b). 6-Bromo-naphthalene-2-carbonyl chloride, Example 1(a), reacted with 3-aminoquinoline (Aldrich) to give the title compound as a green amorphous solid. MS (ESI, pos. ion.) m/z: 377 (M+1).

Workup

  1. customThis material was prepared analogous to the procedure

Sources & evidence

ORD record
ord-cb6b3a5002844e5d826efa67f3137600
Source dataset
uspto-grants-2009_06
Patent number
US07553848B2

Reaction notes

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