Chloroacetone → HCID 57725262, compound

HRID 1987835Notes

Reaction equation

HRID 1987835 reaction equation
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:4][CH:3]=1.Cl[CH2:17][C:18](=O)[CH3:19]>>[CH3:19][C:18]1[CH:1]=[C:2]2[N:7]([CH:17]=1)[CH:6]=[C:5]([NH:8][C:9](=[O:15])[O:10][C:11]([CH3:12])([CH3:14])[CH3:13])[CH:4]=[CH:3]2

Participants

3

Reactant 2

HCID 6571ChloroacetoneHCID 23090429tert-Butyl (6-methylpyridin-3-yl)carbamate

Product 1

HCID 57725262HCID 57725262, compoundYield 31%

Procedure

This compound is obtained according to the same procedure as the compound of Preparation III using the Tschitschibabin reaction, starting with 5.79 g of tert-butyl (6-methylpyridin-3-yl)carbamate [described in J. Med. Chem.; (2000), 43, 5017-5029] and chloroacetone. 1.96 g of a pasty residue are obtained.

Workup

  1. customThis compound is obtained
  2. customthe Tschitschibabin reaction

Sources & evidence

ORD record
ord-e9269e60a04c460f905155d344f4031b
Source dataset
uspto-grants-2009_06
Patent number
US07553845B2

Reaction notes

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