HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl crotonate, (E)- → Benzyl [7-{N-(ethoxycarbonyl)amino}-3-(3-methoxy-4-nitrobenzoyl)-2-methylindolizin-1-yl]carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl crotonate, (E)- | HCID 5356259 | — |
| Reactant | 4-[N-(ethoxycarbonyl)amino]-1-[2-(3-methoxy-4-nitrophenyl)-2-oxoethyl]pyridinium bromide | HCID 86607555 | — |
| Catalyst | Manganese oxide | HCID 160959 | — |
| Product | Benzyl [7-{N-(ethoxycarbonyl)amino}-3-(3-methoxy-4-nitrobenzoyl)-2-methylindolizin-1-yl]carboxylate | HCID 86607557 | 26% |
Reaction Steps
This compound is prepared according to the same method as that described in Example 47 Step B from 1.8 g (4.1 mmol) of 4-[N-(ethoxycarbonyl)amino]-1-[2-(3-methoxy-4-nitrophenyl)-2-oxoethyl]pyridinium bromide with benzyl crotonate in the presence of manganese oxide as oxidizing agent. 573 mg of a yellow powder are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07553845B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-d5ad3b8667ee4e1cb3475e35f2fcbae8 |
| Source note | uspto-grants-2009_06 |