Trifluoroacetic acid → HCID 68849488, compound

HRID 1987846Notes

Reaction equation

[NH2:1][C:2]1[CH:35]=[CH:34][C:5]([C:6]([C:8]2[N:16]3[C:11]([CH:12]=[CH:13][C:14]([NH:17]C(=O)OC(C)(C)C)=[CH:15]3)=[C:10]([C:25]3[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][CH:26]=3)[C:9]=2[CH3:33])=[O:7])=[CH:4][C:3]=1[O:36][CH3:37].FC(F)(F)C(O)=O>>[NH2:1][C:2]1[CH:35]=[CH:34][C:5]([C:6]([C:8]2[N:16]3[C:11]([CH:12]=[CH:13][C:14]([NH2:17])=[CH:15]3)=[C:10]([C:25]3[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][CH:26]=3)[C:9]=2[CH3:33])=[O:7])=[CH:4][C:3]=1[O:36][CH3:37]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 86607558HCID 86607558, compound

Product 1

HCID 68849488HCID 68849488, compound

Procedure

This compound is prepared according to the same method as that described in Example 49 by unblocking tert-butyl [3-(4-amino-3-methoxybenzoyl)-1-(4-methoxyphenyl)-2-methylindolizin-6-yl]carbamate with trifluoroacetic acid.

Workup

customThis compound is prepared

Sources & evidence

ORD record: ord-9922b7ce19434792bcca5feac5eb9b1d
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07553845B2

Reaction notes

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