Trifluoroacetic acid → HCID 86607562, compound

HRID 1987848Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[CH:4][N:5]2[C:9]([CH:10]=1)=[C:8]([C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12])[C:7]([CH3:21])=[C:6]2[C:22](=[O:34])[C:23]1[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[C:25]([O:32][CH3:33])[CH:24]=1.F[C:36](F)(F)C(O)=O>>[CH3:33][O:32][C:25]1[CH:24]=[C:23]([CH:28]=[CH:27][C:26]=1[N+:29]([O-:31])=[O:30])[C:22]([C:6]1[N:5]2[C:9]([CH:10]=[C:2]([NH:1][CH3:36])[CH:3]=[CH:4]2)=[C:8]([C:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:12])[C:7]=1[CH3:21])=[O:34]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 86607560HCID 86607560, compound

Product 1

HCID 86607562HCID 86607562, compoundYield 78%

Procedure

This compound is obtained according to the same method as the compound of Example 49 by deprotection of the amino functional group of 849 mg (1.48 mmol) of benzyl [7-[(N-tert-butoxycarbonyl)(N-methyl)amino]-3-(3-methoxy-4-nitrobenzoyl)-2-methylindolizin-1-yl]carboxylate with trifluoroacetic acid. 549 mg of an orange-coloured powder are obtained.

Workup

customThis compound is obtained

Sources & evidence

ORD record: ord-c65fc967f469420bb181f7ef33f9271e
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07553845B2

Reaction notes

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