HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → N-[2-(9-Oxo-9H-xanthen-3-yl)-phenyl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 3-Bromo-9H-xanthen-9-one | HCID 231608 | — |
| Reactant | 2-Acetamidophenylboronic acid | HCID 2737789 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-[2-(9-Oxo-9H-xanthen-3-yl)-phenyl]-acetamide | HCID 57725319 | — |
Reaction Steps
3-Bromo-xanthen-9-one (0.25 g, 0.9 mmol), 2-acetamidophenylboronic acid (0.99 mmol), 1,1′-bis-(diphenylphosphino)ferrocene-palladium (II) dichloride (33 mg, 0.045 mmol), cesium carbonate (0.59 g, 1.8 mmol), dioxane (4 mL), and ethanol (2 mL) were microwaved in a 5-mL reaction vessel at 100° C. for 5 min. The reaction was filtered and concentrated. The residue was purified by reverse phase chromatography to afford N-[2-(9-Oxo-9H-xanthen-3-yl)-phenyl]-acetamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07553850B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-c3dd7df7be094a058fcd97dbe720d316 |
| Source note | uspto-grants-2009_06 |