HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 178513222, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 9-[8-(2,2,2-Trifluoro-acetyl)-8-aza-bicyclo[3.2.1]oct-3-ylidene]-9H-xanthene-3-carbonitrile | HCID 57725339 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178513222 | HCID 178513222 | — |
Reaction Steps
To a suspension of compound 5e (0.44 g, 1.07 mmol) in EtOH (5 mL) were added NH2OH.HCl (0.223 g, 3.19 mmol) and K2CO3 (0.3 g, 2.17 mmol). The reaction mixture was refluxed for 4 h. Upon cooling to room temperature, H2O (1 mL) was added to the mixture. The mixture was extracted with CH2Cl2 (2×5mL), dried (MgSO4), and concentrated to yield compound 6a. The product 6a was used in the next reaction without further purification. MS m/z (MH+) 443.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07553850B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-7efba73226a54ee79455cf77194303d5 |
| Source note | uspto-grants-2009_06 |