反应详情

To a suspension of compound 5e (0.44 g, 1.07 mmol) in EtOH (5 mL) were added NH2OH.HCl (0.223 g, 3.19 mmol) and K2CO3 (0.3 g, 2.17 mmol). The reaction mixture was refluxed for 4 h. Upon cooling to room temperature, H2O (1 mL) was added to the mixture. The mixture was extracted with CH2Cl2 (2×5mL), dried (MgSO4), and concentrated to yield compound 6a. The product 6a was used in the next reaction without further purification. MS m/z (MH+) 443.9.

1. temperatureThe reaction mixture was refluxed for 4 h
2. extractionThe mixture was extracted with CH2Cl2 (2×5mL)
3. dry with materialdried (MgSO4)
4. concentrationconcentrated