Iodoacetamide → HCID 58742321, compound

HRID 1988099Notes

Reaction equation

HRID 1988099 reaction equation
[CH2:1]([C@:3]12[C:16]3[C:11](=[CH:12][C:13]([OH:17])=[CH:14][CH:15]=3)[CH2:10][CH2:9][C@@H:8]1[CH2:7][C@:6]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=1)([OH:18])[C@:5]([CH3:26])([OH:25])[CH2:4]2)[CH3:2].I[CH2:28][C:29]([NH2:31])=[O:30]>>[CH2:1]([C@@:3]12[CH2:4][C@:5]([OH:25])([CH3:26])[C@:6]([OH:18])([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=3)[CH2:7][C@H:8]1[CH2:9][CH2:10][C:11]1[CH:12]=[C:13]([O:17][CH2:28][C:29]([NH2:31])=[O:30])[CH:14]=[CH:15][C:16]2=1)[CH3:2]

Participants

3

Reactant 2

HCID 3727IodoacetamideHCID 10450738HCID 10450738, compound

Product 1

HCID 58742321HCID 58742321, compound

Procedure

The title compound was prepared from the compound of Example 102 according to the procedure of Example 57, running the reaction at room temperature overnight and using iodoacetamide as the alkylating agent. Mass spectrum (m/e) 411 (M++1).

Workup

  1. customthe reaction at room temperature overnight

Sources & evidence

ORD record
ord-b46ef5ee711c4af9812871b164a3f6ad
Source dataset
uspto-grants-2009_06
Patent number
US07553877B2

Reaction notes

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