HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]methanone → 6-Chloro-5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | (4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]methanone | HCID 11603838 | — |
| Edukt | 6-Chloro-5-hydroxy-1H-indole-2-carboxylic acid ethyl ester | HCID 67017914 | — |
| Produkt | 6-Chloro-5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid ethyl ester | HCID 67017926 | — |
Reaktionsschritte
In analogy to the procedure described for the synthesis of intermediate 1, step 2, the title compound was synthesized from 6-chloro-5-hydroxy-1H-indole-2-carboxylic acid ethyl ester (example 39, step 2). The title compound was obtained in 66% yield as light yellow foam. MS (m/e): 365.0 (MH+, 100%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07745479B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-19c304015cc74ae6abbad95415e62a19 |
| Quellennotiz | uspto-grants-2010_06 |