Ammonia → HCID 178461419, compound

HRID 1988133Notes

Reaction equation

HRID 1988133 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:11][C@H:10]([N:12]3[CH2:16][CH2:15][CH2:14][C@@H:13]3[CH3:17])[CH2:9]2)=[CH:4][CH:3]=1.[NH3:18]>>[CH3:17][C@H:13]1[CH2:14][CH2:15][CH2:16][N:12]1[C@H:10]1[CH2:11][C@H:8]([C:5]2[CH:6]=[CH:7][C:2]([C:2]3[CH:7]=[CH:6][C:5]([C:8]#[N:18])=[CH:4][CH:3]=3)=[CH:3][CH:4]=2)[CH2:9]1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 178461416HCID 178461416, compound

Product 1

HCID 178461419HCID 178461419, compound

Procedure

The title compound was prepared using the procedure described in Example 1C except substituting the product from Example 13A for the product from Example 1B. 1H NMR (300 MHz, CD3OD) δ 1.36 (d, J=6 Hz, 3 H), 1.72 (m, 1 H), 2.01 (m, 2 H), 2.24 (m, 1 H), 2.55 (m, 1 H), 2.63 (m, 1 H), 2.78 (m, 2 H), 3.02 (m, 1 H), 3.25 (m, 1 H), 3.42 (m, 1 H), 3.69 (m, 1 H), 3.90 (m, 1 H), 7.47 (d, J=9 Hz, 2 H), 7.68 (d, J=9 Hz, 2 H), 7.80 (AB q, 4 H); (DCl/NH3) m/z 317 (M+H)+.

Sources & evidence

ORD record
ord-3c8060dfa5d6463cab8680df16c7a582
Source dataset
uspto-grants-2009_06
Patent number
US07553964B2

Reaction notes

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