Ammonia → HCID 178461417, compound

HRID 1988137Notes

Reaction equation

HRID 1988137 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[CH2:11][C@H:10](O)[CH2:9]2)=[CH:4][C:3]=1[F:13].[NH3:14]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:11][C@H:10]([N:14]3[CH2:6][CH2:7][CH2:2][C@H:3]3[CH3:4])[CH2:9]2)=[CH:4][C:3]=1[F:13]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 178521620HCID 178521620, compound

Product 1

HCID 178461417HCID 178461417, compound

Procedure

The title compound was prepared using the procedure described in Example 1B except substituting the product from Example 22C for the product from Example 1A. 1H NMR (300 MHz, CD3OD) δ 1.12 (d, J=6 Hz, 3 H), 1.48 (m, 1 H), 1.78 (m, 2 H), 2.00 (m, 1 H), 2.23 (m, 1 H), 2.36 (m, 2 H), 2.59 (m, 3 H), 3 H), 3.03 (m, 1 H), 3.34 (m, 1 H), 3.48 (m, 1 H), 7.06 (dd, J=9 Hz, J=3 Hz, 1 H), 7.17 (dd, J=9 Hz, J=3 Hz, 1 H), 7.53 (t, J=9 Hz, 1 H); (DCl/NH3) m/z 312 (M+H)+.

Sources & evidence

ORD record
ord-109f49224d5f4b398f06e95f0564ed31
Source dataset
uspto-grants-2009_06
Patent number
US07553964B2

Reaction notes

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