Hydrazine hydrate (1:1) → (2S)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanohydrazide

HRID 1988187Notes

Reaction equation

HRID 1988187 reaction equation
[F:1][C:2]([F:11])([F:10])[C@:3]([OH:9])([CH3:8])[C:4](OC)=[O:5].O.[NH2:13][NH2:14]>>[F:1][C:2]([F:11])([F:10])[C@:3]([OH:9])([CH3:8])[C:4]([NH:13][NH2:14])=[O:5]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 53969069HCID 53969069, compound

Product 1

HCID 57729253(2S)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanohydrazide

Conditions

Temperature
130 °C

Procedure

To a solution of methyl(2S)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoate (3.26 g, 19.0 mmol) was added hydrazine monohydrate (2.1 ml). The mixture was heated at 130° C. for 90 min and cooled down to room temperature. After evaporation to dryness, the residue was purified on a small bed of silica gel (100% EtOAc) to afford the title compound.

Workup

  1. temperaturecooled down to room temperature
  2. customAfter evaporation to dryness
  3. customthe residue was purified on a small bed of silica gel (100% EtOAc)

Sources & evidence

ORD record
ord-f213fe6f37f14c8ebe6353f69db09351
Source dataset
uspto-grants-2009_06
Patent number
US07553973B2

Reaction notes

Loading…