反应详情

温度

130 °C

To a solution of methyl(2S)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoate (3.26 g, 19.0 mmol) was added hydrazine monohydrate (2.1 ml). The mixture was heated at 130° C. for 90 min and cooled down to room temperature. After evaporation to dryness, the residue was purified on a small bed of silica gel (100% EtOAc) to afford the title compound.

1. temperaturecooled down to room temperature
2. customAfter evaporation to dryness
3. customthe residue was purified on a small bed of silica gel (100% EtOAc)