反应详情

To a solution of ethyl magnesium bromide (200 mmol) in 300 mL of THF at 0° C. was added a suspension of ethyl 5-amino-1,3,4-oxadiazol-2-carboxylate (8.00 g, 50.9 mmol; Chemical Abstract, 1966, 64, 3558a) in THF. The reaction mixture was brought to rt and 30 min later quenched with NH4Cl. After extraction with EtOAc and drying over MgSO4, the solvent was removed. The crude product thus obtained was triturated, filtered and dried to yield the title compound.

1. customlater quenched with NH4Cl
2. extractionAfter extraction with EtOAc
3. dry with materialdrying over MgSO4
4. customthe solvent was removed
5. customThe crude product thus obtained
6. customwas triturated
7. filtrationfiltered
8. customdried