反应详情

温度

65 °C

To a solution of methyl 4-(2-methyl-1,3-thiazol-4-yl)-2-oxo-2H-chromene-7-carboxylate (1.0 g, 3.32 mmol) in THF (33 ml) was added lithium hydroxide 1 M (16.6 ml, 16.6 mmol). The reaction was heated at 65° C. for 90 min, cooled to rt and evaporated. A solution of HCl 2N was then added to the residue and the mixture stirred for 1 h. The powder was filtered to give the title compound. 1H NMR (400 MHz, DMSO-d6): δ 8.37 (m, 1H), 8.28 (s, 1H), 7.87 (m, 2H), 6.85 (s, 1H), 2.80 (s, 3H).

1. temperaturecooled to rt
2. customevaporated
3. additionA solution of HCl 2N was then added to the residue
4. filtrationThe powder was filtered