関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Gamma-Valerolactone | HCID 7921 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | O-Methylhydroxylamine hydrochloride | HCID 521874 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-Hydroxy-pentanoic acid methoxy-methyl-amide | HCID 79193213 | — |
反応手順
To a solution of 5-methyl-dihydro-furan-2-one (0.2 m L, 2.1 m mol) in dichloromethane (10 mL) was added a mixture of AlCl3 (3.1 mL, 6.2 mmol) and methoxylamine hydrochloride (0.6 g, 6.2 mmol) in dichloromethane (20 mL). After 1.5 hours, the reaction was cooled to 0° C. and a saturated sodium bicarbonate solution (10 mL) was added slowly. Extraction and concentration afforded 4-hydroxy-pentanoic acid methoxy-methyl-amide as a clear oil (184 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07553979B2 |
|---|
| 出典データセット | uspto-grants-2009_06 |
|---|
| ORD ID | ord-be0be33fab3f43d0b1541ccc9a69b876 |
|---|
| 出典メモ | uspto-grants-2009_06 |
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