反应详情

温度

0 °C

To a solution of 5-methyl-dihydro-furan-2-one (0.2 m L, 2.1 m mol) in dichloromethane (10 mL) was added a mixture of AlCl3 (3.1 mL, 6.2 mmol) and methoxylamine hydrochloride (0.6 g, 6.2 mmol) in dichloromethane (20 mL). After 1.5 hours, the reaction was cooled to 0° C. and a saturated sodium bicarbonate solution (10 mL) was added slowly. Extraction and concentration afforded 4-hydroxy-pentanoic acid methoxy-methyl-amide as a clear oil (184 mg).

1. extractionExtraction and concentration