反应详情

A mixture of Z-N-Me-Val-N-Me-Tyr(3-tBu)-NH2 (0.98 g, 1.97 mmol) and 20% palladium hydroxide/carbon (0.10 g) in methanol (20 ml) was stirred at room temperature in a hydrogen atmosphere for 1.5 hours. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure; the thus obtained residue was subjected to silica gel column chromatography (developing solvent: chloroform:methanol:aqueous ammonia=100:10:1) to give N-Me-Val-N-Me-Tyr(3-tBu)-NH2 (0.71 g, 99%).

1. filtrationThe reaction mixture was filtered
2. concentrationthe filtrate was concentrated under reduced pressure