HuagongsheHuagongshe Chemistry Print Report · For research reference only
Z-N-Me-Val-N-Me-Tyr(3-tBu)-NHOMe → N-Me-Val-N-Me-Tyr(3-tBu)-NHOMe
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Z-N-Me-Val-N-Me-Tyr(3-tBu)-NHOMe | HCID 131727511 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-Me-Val-N-Me-Tyr(3-tBu)-NHOMe | HCID 131727513 | 99.2% |
Reaction Steps
To a solution of Z-N-Me-Val-N-Me-Tyr(3-tBu)-NHOMe (1.23 g, 2.33 mmol) in MeOH (20 ml), palladium hydroxide/carbon (350 mg) was added and stirred in a hydrogen atmosphere for 1 hour. Insoluble matters were removed by filtration with Celite and the filtrate was concentrated under reduced pressure to give crude N-Me-Val-N-Me-Tyr(3-tBu)-NHOMe (0.91 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07553969B1 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-538f2e9b2b6d49fa80ef73c978b7d728 |
| Source note | uspto-grants-2009_06 |