反应详情

A mixture of the thus obtained Z-N-Me-Val-Tyr(3-tBu)-NH2 (1.7 g), 20% palladium hydroxide/carbon (0.15 g) and methanol (30 ml) was stirred at room temperature in a hydrogen atmosphere for 1 hour. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure; the thus obtained residue was subjected to silica gel column chromatography (developing solvent: methylene chloride:methanol=10:1), giving the titled compound (1.07 g, 88%).

1. filtrationThe reaction mixture was filtered
2. concentrationthe filtrate was concentrated under reduced pressure