反应详情

To a solution of Boc-Tyr(2-F)-N-Me-Val-N-Me-Tyr(3-tBu)-NH2 (0.21 g, 0.326 mmol) in methylene chloride (3 ml), TFA (1.5 ml) was added and stirred for 15 min. The reaction mixture was concentrated under reduced pressure, mixed with a saturated aqueous NaHCO3 solution, and extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate. The resultant was evaporated to remove the solvent under reduced pressure, giving the titled compound (173 mg, 82%).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. additionmixed with a saturated aqueous NaHCO3 solution
3. extractionextracted with chloroform
4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
5. customThe resultant was evaporated
6. customto remove the solvent under reduced pressure