HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium hydroxide, monohydrate → Z-Tyr(3-tBu)-OH
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | 3-(1,1-Dimethylethyl)-N-[(phenylmethoxy)carbonyl]-L-tyrosine methyl ester | HCID 15549489 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | Z-Tyr(3-tBu)-OH | HCID 131727524 | 100.7% |
Reaction Steps
To a solution of Z-Tyr(3-tBu)-OMe (1.01 g, 2.62 mmol) in methanol/water (12 ml/3 ml), lithium hydroxide monohydrate (0.17 g, 3.93 mmol) was added and stirred at room temperature for 2 hours. The reaction mixture was washed with ether, rendered acidic by 2N hydrochloric acid and extracted with methylene chloride. The extract was dried over anhydrous magnesium sulfate and evaporated to remove the solvent under reduced pressure, giving crude Z-Tyr(3-tBu)-OH (0.98 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07553969B1 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-8a8a766cf14e425ba70672a4f35f27bb |
| Source note | uspto-grants-2009_06 |