反应详情

To a solution of Z-Tyr(3-tBu)-OMe (1.01 g, 2.62 mmol) in methanol/water (12 ml/3 ml), lithium hydroxide monohydrate (0.17 g, 3.93 mmol) was added and stirred at room temperature for 2 hours. The reaction mixture was washed with ether, rendered acidic by 2N hydrochloric acid and extracted with methylene chloride. The extract was dried over anhydrous magnesium sulfate and evaporated to remove the solvent under reduced pressure, giving crude Z-Tyr(3-tBu)-OH (0.98 g).

1. washThe reaction mixture was washed with ether
2. extractionextracted with methylene chloride
3. dry with materialThe extract was dried over anhydrous magnesium sulfate
4. customevaporated
5. customto remove the solvent under reduced pressure