Dichloromethane → HCID 178486855, compound

HRID 198830Notes

Reaction equation

[CH2:47]([Cl:48])[Cl:49].[Cl:8][c:9]1[c:10]([F:46])[c:11]([NH:12][c:13]2[n:14][cH:15][n:16][c:17]3[cH:18][c:19]([O:41][CH3:42])[c:20]([O:23][CH:24]4[CH2:25][CH:26]([C:36]([N:37]([CH3:38])[CH3:39])=[O:40])[N:27]([C:29]([O:30][C:31]([CH3:32])([CH3:33])[CH3:34])=[O:35])[CH2:28]4)[cH:21][c:22]23)[cH:43][cH:44][cH:45]1.[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[Cl:8][c:9]1[c:10]([F:46])[c:11]([NH:12][c:13]2[n:14][cH:15][n:16][c:17]3[cH:18][c:19]([O:41][CH3:42])[c:20]([O:23][CH:24]4[CH2:25][CH:26]([C:36]([N:37]([CH3:38])[CH3:39])=[O:40])[NH:27][CH2:28]4)[cH:21][c:22]23)[cH:43][cH:44][cH:45]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 69837874Tert-butyl 4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy-2-(dimethylcarbamoyl)pyrrolidine-1-carboxylate

Product 1

HCID 178486855HCID 178486855, compound

Sources & evidence

ORD record: ord-1157f11f382d4b88ad4e4f1637e8895d
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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