Hydrochloric Acid → HCID 69053496, compound

HRID 1988381Notes

Reaction equation

HRID 1988381 reaction equation
[NH2:1][CH2:2][CH:3]([OH:30])[CH2:4][N:5]1[C:9]([CH3:10])=[CH:8][C:7]([C:11]2[CH:12]=[CH:13][C:14]([Cl:29])=[C:15]([CH:28]=2)[C:16]([NH:18][CH2:19][C:20]2([OH:27])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)=[O:17])=[N:6]1.Cl>ClCCl.CCOCC>[ClH:29].[NH2:1][CH2:2][CH:3]([OH:30])[CH2:4][N:5]1[C:9]([CH3:10])=[CH:8][C:7]([C:11]2[CH:12]=[CH:13][C:14]([Cl:29])=[C:15]([CH:28]=2)[C:16]([NH:18][CH2:19][C:20]2([OH:27])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)=[O:17])=[N:6]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 9845817HCID 9845817, compound

Product 1

HCID 69053496HCID 69053496, compoundYield 176%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolvent2×HCID 6344DichloromethaneSolvent

Procedure

To a solution of 5-[1-(3-Amino-2-hydroxy-propyl)-5-methyl-1H-pyrazol-3-yl]-2-chloro-N-(1-hydroxy-cycloheptylmethyl)-benzamide (1.05 g, 2.41 mmol) in dichloromethane (10.0 mL) was added 2.0 N Hydrochloric acid in diethylether (4.0 mL, 8.0 mmol). The mixture was diluted with ether (50 mL) and stirred for 15 min. The precipitated solids were collected by filtration, washed with ether and dried to give title compound (1.0 g): LCMS (m/z) 435.3 M+1.

Workup

  1. filtrationThe precipitated solids were collected by filtration
  2. washwashed with ether
  3. customdried

Sources & evidence

ORD record
ord-7ed41f1bd8864b6698a6b0be4ad8c7d5
Source dataset
uspto-grants-2009_06
Patent number
US07553972B2

Reaction notes

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